Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900082 | 0.90 | CA2 (0.46) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL19533102 | 0.90 | CA2 (0.46) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL12251347 | 0.90 | CA2 (0.46) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL20048987 | 0.88 | CA2 (0.44) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL6763814 | 0.87 | CA2 (0.48) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL25449841 | 0.86 | CA2 (0.43) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL21240104 | 0.86 | CA2 (0.43) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL9626868 | 0.85 | GABRA1 (0.56) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL3106199 | 0.83 | CA2 (0.44) | CA2GABRA1GABRB2ALDH1A1TSHR | |
| SCHEMBL12024755 | 0.83 | ALDH1A1 (0.60) | CA2GABRA1GABRB2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046689-B2 | Selective estrogen receptor down-regulators | ASTRAZENECA AB (SE) | 2021-06-29 | — | — | US | disclosed |
| US-20200239468-A1 | Selective Estrogen Receptor Down-Regulators | ASTRAZENECA PHARMACEUTICALS LP | 2020-07-30 | — | — | US | disclosed |
| WO-2020124397-A1 | C-TERMINAL SRC KINASE INHIBITORS | INVENTISBIO SHANGHAI LTD. (CN) | 2020-06-25 | — | — | WO | disclosed |
| US-10590132-B2 | Selective estrogen receptor down-regulators | ASTRAZENECA AB (SE) | 2020-03-17 | — | — | US | disclosed |
| US-20190233413-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2019-08-01 | — | — | US | disclosed |
| US-10221173-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2019-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590132-B2 | Selective estrogen receptor down-regulators | ESR2, ESRRB, ESRRA | CA2 4517/4885GABRA1 1214/4885GABRB2 629/4885 |
| US-20190233413-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | CA2 2040/4885GABRA1 3149/4885GABRB2 2791/4885 |
| US-10221173-B2 | Chemical compounds | MKI67, CCNI, MCL1 | CA2 2040/4885GABRA1 3149/4885GABRB2 2791/4885 |
| US-11046689-B2 | Selective estrogen receptor down-regulators | ESR2, ESRRB, ESRRA | CA2 4517/4885GABRA1 1214/4885GABRB2 629/4885 |
| US-20200239468-A1 | Selective Estrogen Receptor Down-Regulators | ESR2, ESRRB, ESRRA | CA2 4517/4885GABRA1 1214/4885GABRB2 629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.