Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | ITGAL | P20701 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.45 |
| ▸ | WNT3A | P56704 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 2/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL28202465 | 0.98 | ITGB2 (0.52) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| SCHEMBL28007596 | 0.98 | ITGB2 (0.52) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| SCHEMBL29356442 | 0.98 | ITGB2 (0.52) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| SCHEMBL8447 | 0.98 | ITGB2 (0.52) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| SCHEMBL5313090 | 0.98 | ITGB2 (0.52) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| SCHEMBL7650589 | 0.95 | ITGB2 (0.50) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| Water SCHEMBL5189676 | 0.95 | ITGB2 (0.50) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| Iodide SCHEMBL30543385 | 0.95 | ITGB2 (0.50) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| Bromide SCHEMBL11373619 | 0.95 | ITGB2 (0.50) | ITGB2ICAM1ITGALTSHRCTNNB1 | |
| Water SCHEMBL7527071 | 0.95 | ITGB2 (0.50) | ITGB2ICAM1ITGALTSHRCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103012380-B | Chroman compound, and preparation method and application thereof | UNIV SHANDONG | 2015-03-04 | — | — | CN | claimed |
| CN-103012380-A | Chroman compound, and preparation method and application thereof | UNIV SHANDONG | 2013-04-03 | — | — | CN | claimed |
| CN-1714089-A | Novel use of substituted aminomethyl chromans | MERCK PATENT GMBH (DE) | 2005-12-28 | — | — | CN | claimed |
| CN-105555775-A | Process for preparing medicaments for the treatment of cardiovascular diseases and intermediates used therein | BIAL - PORTELA & CA S A | 2016-05-04 | — | — | CN | disclosed |
| CN-103012380-B | Chroman compound, and preparation method and application thereof | UNIV SHANDONG | 2015-03-04 | — | — | CN | disclosed |
| CN-102714309-B | Anode material for electrochemical cells and a method for producing same | ELIONT LLC | 2015-02-18 | — | — | CN | disclosed |
| US-8552181-B2 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-10-08 | — | — | US | disclosed |
| CN-103012380-A | Chroman compound, and preparation method and application thereof | UNIV SHANDONG | 2013-04-03 | — | — | CN | disclosed |
| CN-102714309-A | Anode material for electrochemical cells and a method for producing same | ELIONT LLC | 2012-10-03 | — | — | CN | disclosed |
| US-20120220583-A1 | SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2012-08-30 | — | — | US | disclosed |
| US-8163909-B2 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2012-04-24 | — | — | US | disclosed |
| WO-2003090690-A2 | CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH | GILEAD SCIENCES, INC. (US) | 2003-11-06 | — | — | WO | disclosed |
| EP-1343778-A2 | DI-SUBSTITUTED AMINOMETHYL CHROMAN DERIVATIVE BETA-3 ADRENORECEPTOR AGONISTS | Bayer Corporation (US) | 2003-09-17 | — | — | EP | disclosed |
| US-20030078260-A1 | 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists | BAYER PHARMACEUTICALS CORPORATION | 2003-04-24 | — | — | US | disclosed |
| US-20030078258-A1 | Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists | BAYER PHARMACEUTICALS CORPORATION | 2003-04-24 | — | — | US | disclosed |
| WO-2002085891-A1 | 2,6-SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2002-10-31 | — | — | WO | disclosed |
| WO-2002048134-A2 | DI-SUBSTITUTED AMINOMETHYL CHROMAN DERIVATIVE BETA-3 ADRENORECEPTOR AGONISTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2002-06-20 | — | — | WO | disclosed |
| CN-1340220-A | Improved lithium manganese oxide based active materials | VALENCE TECHNOLOGY INC (US) | 2002-03-13 | — | — | CN | disclosed |
| US-5846942-A | Cholecystokinin antagonists, their preparation and therapeutic use | WARNER-LAMBERT COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| US-5593967-A | Cholecystokinin antagonists, their preparation and therapeutic use | WARNER-LAMBERT COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078260-A1 | 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists | ADRB3, ADRB2, ADRB1 | ITGB2 856/4885ICAM1 2227/4885ITGAL 1013/4885 |
| US-20120220583-A1 | SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | ITGB2 3124/4885ICAM1 2967/4885ITGAL 2383/4885 |
| US-20030078258-A1 | Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists | ADRB3, ADRB1, ADRB2 | ITGB2 949/4885ICAM1 2020/4885ITGAL 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.