Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.36 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 5/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22407387 | 0.81 | ENPP1 (0.66) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| SCHEMBL22407385 | 0.81 | ENPP3 (0.47) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| SCHEMBL22436143 | 0.64 | ENPP3 (0.67) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| SCHEMBL9159084 | 0.64 | GRM4 (0.67) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| SCHEMBL9139295 | 0.63 | TLR8 (0.59) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL20771109 | 0.63 | ENPP3 (0.66) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| SCHEMBL3841526 | 0.63 | HTR1A (0.58) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| SCHEMBL28436096 | 0.62 | TLR8 (0.61) | ENPP3ENPP1HTR1AADRA1DADRA1A | |
| SCHEMBL25620299 | 0.62 | MET (0.52) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL20770893 | 0.62 | ENPP1 (1.00) | ENPP3ENPP1HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046778-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | MAVUPHARMA, INC. (US) | 2019-03-07 | — | — | WO | disclosed |