Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20783033 | 0.84 | TRPA1 (0.40) | JAK2PRKCQROCK1NUDT1ROCK2 | |
| SCHEMBL24445800 | 0.81 | JAK2 (0.40) | PRKACAJAK2JAK3PRKCQROCK1 | |
| SCHEMBL20783145 | 0.80 | NUDT1 (0.43) | NUDT1 | |
| SCHEMBL10124925 | 0.80 | IGF1R (0.58) | PRKACAJAK2JAK3PRKCQROCK1 | |
| SCHEMBL20783030 | 0.79 | CDK9 (0.45) | CDK7CDK9GSK3BCDK1CDK2 | |
| SCHEMBL24445629 | 0.76 | PIK3C3 (0.48) | PRKACAJAK2JAK3PRKCQROCK1 | |
| SCHEMBL20782478 | 0.72 | PIK3C3 (0.45) | MAPK8GSK3BEGFR | |
| SCHEMBL20782273 | 0.69 | PIK3C3 (0.47) | CLK4AAK1CDC7 | |
| SCHEMBL24240602 | 0.69 | PIK3C3 (0.46) | JAK2AAK1 | |
| SCHEMBL20776165 | 0.68 | PIK3C3 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038384-A1 | AZAINDOLYLPYRIDONE AND DIAZAINDOLYLPYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2019-02-28 | — | — | WO | disclosed |