Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 14/20 | 0.64 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1988198 | 0.87 | RPA1 (0.58) | RPA1PPP1CAKMT2AMEN1 | |
| SCHEMBL1514551 | 0.81 | RPA1 (0.76) | RPA1PPP1CAKMT2AMEN1 | |
| SCHEMBL20786116 | 0.81 | PDPK1 (0.46) | RPA1 | |
| SCHEMBL27811241 | 0.77 | BRD4 (0.55) | RPA1KMT2AMEN1 | |
| SCHEMBL27831427 | 0.75 | MARS1 (0.53) | KMT2AMEN1 | |
| SCHEMBL27811119 | 0.74 | BRD4 (0.52) | KMT2AMEN1 | |
| SCHEMBL5772366 | 0.71 | KDM4E (0.46) | KMT2AMEN1 | |
| SCHEMBL4488941 | 0.71 | KMT2A (0.82) | RPA1PPP1CAKMT2AMEN1 | |
| SCHEMBL1986774 | 0.70 | RPA1 (0.77) | RPA1PPP1CA | |
| SCHEMBL28791272 | 0.70 | SMPD1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040511-A1 | DUAL INHIBITORS OF THE BCL-2 AND HDM2 FAMILIES THROUGH CO-MIMICRY OF THE BH3 AND P53-ALPHA-HELICES | UNIVERSITY OF MARYLAND BATIMORE (US) | 2019-02-28 | — | — | WO | disclosed |