Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | RPA1 | P27694 | 8/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.43 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20786115 | 0.81 | RPA1 (0.64) | RPA1 | |
| SCHEMBL20785642 | 0.70 | BCL2L1 (0.53) | RPA1PTGS2PTGS1MAPK9MALT1 | |
| SCHEMBL1988198 | 0.69 | RPA1 (0.58) | PDPK1RPA1 | |
| SCHEMBL21317269 | 0.67 | FLT1 (0.55) | FLT1FLT4KDRPTGS2PTGS1 | |
| SCHEMBL27907764 | 0.67 | PDPK1 (0.48) | PDPK1MALT1 | |
| SCHEMBL1514551 | 0.64 | RPA1 (0.76) | RPA1 | |
| SCHEMBL21317155 | 0.63 | KMO (0.55) | RPA1FLT1FLT4KDRPTGS2 | |
| SCHEMBL674910 | 0.63 | CNR1 (0.60) | RPA1FLT1FLT4KDR | |
| SCHEMBL27851807 | 0.63 | MALT1 (0.49) | MALT1 | |
| SCHEMBL14119814 | 0.62 | KMT2A (0.47) | RPA1PTGS2MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040511-A1 | DUAL INHIBITORS OF THE BCL-2 AND HDM2 FAMILIES THROUGH CO-MIMICRY OF THE BH3 AND P53-ALPHA-HELICES | UNIVERSITY OF MARYLAND BATIMORE (US) | 2019-02-28 | — | — | WO | disclosed |