Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 5/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330380 | 0.84 | MAPT (0.56) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL6831160 | 0.80 | MAPT (0.55) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL11546922 | 0.79 | MAPT (0.76) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL3973537 | 0.78 | MAPT (0.69) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL5763991 | 0.75 | MAPT (0.76) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL20788520 | 0.75 | FYN (0.46) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL20529653 | 0.74 | MAPT (0.49) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL28002244 | 0.74 | MAPT (0.65) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL31570099 | 0.74 | MAPT (0.58) | MAPTLMNAALDH1A1KMT2ATDP1 | |
| SCHEMBL31365106 | 0.74 | MAPT (0.68) | MAPTLMNAALDH1A1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190076552-A1 | Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases | INSTITUTE OF NUCLEAR ENERGY RESEARCH, NUCLEAR ENERGY COUNCIL, EXECUTIVE YUAN (TW) | 2019-03-14 | — | — | US | claimed |
| US-10507250-B2 | Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases | INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN (TW) | 2019-12-17 | — | — | US | disclosed |
| US-20190076552-A1 | Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases | INSTITUTE OF NUCLEAR ENERGY RESEARCH, NUCLEAR ENERGY COUNCIL, EXECUTIVE YUAN (TW) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10507250-B2 | Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases | H1-3, H1-2, HDAC2 | MAPT 54/4885LMNA 181/4885ALDH1A1 2263/4885 |
| US-20190076552-A1 | Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases | H1-3, H1-2, HDAC2 | MAPT 54/4885LMNA 181/4885ALDH1A1 2263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.