Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12655740 | 0.84 | KDM4E (0.70) | KDM4EHTTPOLBHPGDGRM3 | |
| SCHEMBL12626113 | 0.80 | KDM4E (0.64) | KDM4EHTTPOLBHPGDALDH1A1 | |
| SCHEMBL12655508 | 0.79 | HTT (0.62) | KDM4EHTTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL12626097 | 0.78 | KDM4E (0.61) | KDM4EHTTPOLBHPGDGRM3 | |
| SCHEMBL25495300 | 0.73 | HTT (0.56) | KDM4EHTTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13353200 | 0.72 | POLB (0.68) | KDM4EHTTPOLBHPGDGRM3 | |
| SCHEMBL12622121 | 0.71 | HTT (0.53) | KDM4EHTTPOLBHPGDALDH1A1 | |
| SCHEMBL12656202 | 0.71 | POLB (0.38) | KDM4EHTTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL20195339 | 0.69 | PTGIR (0.51) | KDM4EHTTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL15082081 | 0.69 | CA1 (0.48) | HPGDALDH1A1SMN1; SMN2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10222368-B2 | Alzheimer's disease assay in a living patient | PAIN THERAPEUTICS, INC. (US) | 2019-03-05 | — | — | US | disclosed |