Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 3/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215225 | 0.75 | TRIM24 (0.42) | TRIM24TRIM33AGTR1AGTR2KMT2A | |
| SCHEMBL29954331 | 0.74 | TRIM24 (0.52) | TRIM24TRIM33AGTR1AGTR2KMT2A | |
| SCHEMBL12253115 | 0.74 | TRIM24 (0.52) | TRIM24TRIM33AGTR1AGTR2KMT2A | |
| SCHEMBL832535 | 0.72 | TRIM24 (0.42) | TRIM24TRIM33AGTR1AGTR2KMT2A | |
| SCHEMBL16570096 | 0.71 | TRIM24 (0.44) | TRIM24TRIM33KMT2AL3MBTL1NPC1 | |
| SCHEMBL14817464 | 0.71 | TRIM24 (0.41) | TRIM24TRIM33AGTR1AGTR2KMT2A | |
| SCHEMBL12873564 | 0.69 | TAAR1 (0.36) | LATS1LATS2KMT2AL3MBTL1MEN1 | |
| SCHEMBL3902421 | 0.69 | FFAR2 (0.39) | TRIM24TRIM33AGTR1AGTR2ALDH1A1 | |
| SCHEMBL2557955 | 0.69 | TRIM24 (0.53) | TRIM24TRIM33KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9768756 | 0.67 | TRIM24 (0.52) | TRIM24TRIM33KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |