Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18378462 | 0.79 | HTT (0.44) | ALDH1A1GLATSHRHTTNPC1 | |
| SCHEMBL832535 | 0.78 | TRIM24 (0.42) | TRIM24TRIM33AGTR1AGTR2ALDH1A1 | |
| SCHEMBL18186740 | 0.78 | OPRM1 (0.46) | ALDH1A1GLATSHRHTTL3MBTL1 | |
| SCHEMBL1353016 | 0.77 | TRIM24 (0.41) | TRIM24TRIM33AGTR1AGTR2ALDH1A1 | |
| SCHEMBL14291609 | 0.76 | POLB (0.45) | TSHRMEN1KMT2APOLBLMNA | |
| SCHEMBL20797705 | 0.75 | TRIM24 (0.42) | TRIM24TRIM33AGTR1AGTR2ALDH1A1 | |
| SCHEMBL29954331 | 0.74 | TRIM24 (0.52) | TRIM24TRIM33AGTR1AGTR2ALDH1A1 | |
| SCHEMBL12253115 | 0.74 | TRIM24 (0.52) | TRIM24TRIM33AGTR1AGTR2ALDH1A1 | |
| SCHEMBL6306623 | 0.71 | SMN1; SMN2 (0.47) | ALDH1A1GLATSHRHTTKDM4E | |
| SCHEMBL14817464 | 0.71 | TRIM24 (0.41) | TRIM24TRIM33AGTR1AGTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013213-B1 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2011-07-27 | — | — | EP | disclosed |