Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 4/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20798386 | 1.00 | PDE10A (0.39) | PDE10AGSK3BNPC1LTA4HNISCH | |
| SCHEMBL21187104 | 0.79 | NISCH (0.36) | GSK3BNPC1LTA4HNISCHMEN1 | |
| SCHEMBL26373004 | 0.79 | LTA4H (0.34) | GSK3BNPC1LTA4HNISCHMEN1 | |
| SCHEMBL18475831 | 0.78 | LTA4H (0.36) | GSK3BNPC1LTA4HNISCHMEN1 | |
| SCHEMBL27529870 | 0.76 | RIPK1 (0.35) | GSK3BNPC1LTA4HNISCHMEN1 | |
| SCHEMBL13757115 | 0.76 | RIPK1 (0.39) | PDE10ANPC1LTA4HNISCHMEN1 | |
| SCHEMBL29908494 | 0.74 | RIPK1 (0.39) | PDE10ANPC1LTA4HNISCHMEN1 | |
| SCHEMBL19859198 | 0.74 | RIPK1 (0.41) | NPC1LTA4HMEN1KMT2ARIPK1 | |
| SCHEMBL19957897 | 0.73 | GSK3B (0.41) | GSK3BNPC1LTA4HMEN1KMT2A | |
| SCHEMBL14841239 | 0.72 | RIPK1 (0.35) | LTA4HNISCHRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |