Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | TGM2 | P21980 | 2/20 | 0.35 |
| ▸ | F13A1 | P00488 | 1/20 | 0.35 |
| ▸ | TGM1 | P22735 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 3/20 | 0.34 |
| ▸ | CTSB | P07858 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21418054 | 0.87 | TPSAB1 (0.34) | TPSAB1PRSS1ABCB1TGM2F13A1 | |
| SCHEMBL19884607 | 0.85 | TPSAB1 (0.41) | TPSAB1PRSS1ABCB1TSHRKDM4E | |
| SCHEMBL24336897 | 0.83 | MEN1 (0.47) | TPSAB1PRSS1TSHRKDM4EALDH1A1 | |
| SCHEMBL22915323 | 0.81 | PARP10 (0.41) | TPSAB1PRSS1ABCB1ALDH1A1NPC1 | |
| SCHEMBL7794342 | 0.79 | ABCB1 (0.50) | ABCB1ALDH1A1HPGDMAPK1CTSL | |
| SCHEMBL21875528 | 0.76 | HSD17B10 (0.46) | HSD17B10 | |
| SCHEMBL21849676 | 0.75 | TPSAB1 (0.39) | TPSAB1PRSS1ABCB1TSHRKDM4E | |
| SCHEMBL15602579 | 0.74 | TRPV1 (0.40) | TPSAB1PRSS1MAPT | |
| SCHEMBL19146965 | 0.74 | TRPV1 (0.40) | TPSAB1PRSS1MAPT | |
| SCHEMBL21697889 | 0.72 | TPSAB1 (0.40) | TPSAB1PRSS1ABCB1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3545969-B1 | DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES | SEAGEN INC (US) | 2023-12-13 | — | — | EP | disclosed |
| EP-3545969-A1 | DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES | Seattle Genetics, Inc. (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-2376110-B1 | WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES | SEATTLE GENETICS INC (US) | 2019-03-13 | — | — | EP | disclosed |