Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.57 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.53 |
| ▸ | WNT3A | P56704 | 3/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8564384 | 0.98 | CES2 (0.57) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL2470002 | 0.83 | CTNNB1 (0.71) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL253276 | 0.83 | CES2 (0.64) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL29355245 | 0.83 | CES2 (0.64) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL7446742 | 0.82 | CTNNB1 (0.57) | CES2CES1LMNANAPRTP4HTM | |
| Hydrochloric Acid SCHEMBL28483161 | 0.81 | CTNNB1 (0.55) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL2639445 | 0.81 | CES2 (0.61) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL422632 | 0.81 | CES2 (0.61) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL422631 | 0.81 | CES2 (0.61) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL156496 | 0.79 | ALDH1A1 (0.61) | CES2CES1LMNANAPRTP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2231486-A | — | — | None | — | — | JP | disclosed |
| CN-118598801-A | Preparation method of acetyl pyridine compound | 帕潘纳(北京)科技有限公司 | 2024-09-06 | — | — | CN | disclosed |
| CN-110117285-B | Inhibitors of influenza virus replication and uses thereof | 广东东阳光药业有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-105658322-B | Clay/polymer blends as high pH or ionic liquid barriers | 艾莫考国际公司 | 2021-04-09 | — | — | CN | disclosed |
| EP-2768822-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-12-06 | — | — | EP | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-20130102576-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-25 | — | — | US | disclosed |
| US-20130102576-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-25 | — | — | US | disclosed |
| US-8183263-B2 | Heteroaryl substituted thiazoles | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| WO-2003027096-A1 | SUBSTITUTED 3-PYRIDYL IMIDAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
| US-5846791-A | N-(R)-(2-hydroxy-2-pyridine-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide | MERCK & CO., INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5792871-A | BETA-3 AGONIST USEFUL IN TREATMENT OF OBESITY AND DIABETES | MERCK & CO., INC. (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998003672-A9 | N-(R)-(2-HYDROXY-2-PYRIDINE-3-YL-ETHYL)-2-(4-NITRO-PHENYL)-ACETAMIDE | — | 1998-04-23 | — | — | WO | disclosed |
| WO-1998003672-A1 | N-(R)-(2-HYDROXY-2-PYRIDINE-3-YL-ETHYL)-2-(4-NITRO-PHENYL)-ACETAMIDE | MERCK & CO., INC. (US) | 1998-01-29 | — | — | WO | disclosed |
| US-5030640-A | Alpha-heterocyclic ethanolamino alkylindoles, growth promoters and feed efficiency agents for animals, bronchodilators, antidepressants, antiobesity agents | MERCK & CO., INC. (US) | 1991-07-09 | — | — | US | disclosed |
| US-5019578-A | β-adrenergic agonists | MERCK & CO., INC. (US) | 1991-05-28 | — | — | US | disclosed |
| JP-H02231486-A | NOVEL BETA-ADRENERGIC AGONIST | MERCK & CO INC | 1990-09-13 | — | — | JP | disclosed |
| EP-0377488-A1 | Novel beta-adrenergic agonists | MERCK & CO. INC. (US) | 1990-07-11 | — | — | EP | disclosed |
| EP-0318092-A2 | Novel beta-adrenergic agonists | MERCK & CO. INC. (US) | 1989-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102576-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE3A, PDE4B | CES2 519/4885CES1 198/4885LMNA 1956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.