Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RHEB | Q15382 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20804449 | 0.86 | FAAH (0.34) | FAAHMAP2K4ROCK2CHEK2PRKACA | |
| SCHEMBL30316429 | 0.82 | MAP2K4 (0.36) | FAAHMAP2K4ELANELMNAGABRG2 | |
| SCHEMBL931118 | 0.79 | ELANE (0.43) | MAP2K4ELANEGABRG2GABRB3GABRA5 | |
| SCHEMBL11232 | 0.79 | PDGFRA (0.47) | MAP2K4SLC22A12ELANE | |
| SCHEMBL24933928 | 0.78 | GABRG2 (0.37) | FAAHMAP2K4SLC22A12KMT2AELANE | |
| SCHEMBL14688976 | 0.78 | GABRG2 (0.37) | FAAHMAP2K4ELANEGABRG2GABRB3 | |
| SCHEMBL20804312 | 0.78 | AXL (0.46) | MAP2K4AURKACDK2 | |
| SCHEMBL26977231 | 0.77 | MAP2K4 (0.34) | FAAHMAP2K4ROCK2CHEK2PRKACA | |
| SCHEMBL832980 | 0.76 | MAP2K4 (0.38) | FAAHMAP2K4ELANEGABRG2GABRB3 | |
| SCHEMBL7605898 | 0.76 | ELANE (0.44) | FAAHMAP2K4SLC22A12ELANELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019051199-A1 | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS | INCYTE CORPORATION (US) | 2019-03-14 | — | — | WO | disclosed |