Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21377412 | 0.78 | ALDH1A1 (0.53) | GAAALDH1A1ALOX12HTTHIF1A | |
| SCHEMBL7687653 | 0.77 | P2RX4 (0.39) | P2RX4P2RX7GAALMNANPC1 | |
| SCHEMBL14446436 | 0.77 | P2RX4 (0.36) | P2RX4P2RX7GAAALDH1A1ALOX12 | |
| SCHEMBL14347188 | 0.77 | P2RX4 (0.44) | P2RX4P2RX7GAAALDH1A1ALOX12 | |
| SCHEMBL5622037 | 0.77 | P2RX4 (0.44) | P2RX4P2RX7GAAALDH1A1ALOX12 | |
| SCHEMBL10618408 | 0.76 | CA1 (0.46) | GAAALDH1A1ALOX12HTTHIF1A | |
| SCHEMBL5470265 | 0.76 | P2RX4 (0.40) | P2RX4P2RX7GAALMNAMAPT | |
| SCHEMBL5470271 | 0.76 | P2RX4 (0.40) | P2RX4P2RX7GAALMNAMAPT | |
| Hydrochloric Acid SCHEMBL5434085 | 0.75 | P2RX4 (0.43) | P2RX4P2RX7GAAALDH1A1ALOX12 | |
| Hydrochloric Acid SCHEMBL20820088 | 0.74 | CA1 (0.44) | GAAALDH1A1ALOX12HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007773-B1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2007773-B1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| US-7902183-B2 | Thiazolyl-dihydro-indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| US-7902183-B2 | Thiazolyl-dihydro-indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| US-7902183-B2 | Thiazolyl-dihydro-indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| CN-101443335-A | Thiazolyl dihydro-indazoles | BOEHRINGER INGELHEIM INT (DE) | 2009-05-27 | — | — | CN | disclosed |
| EP-2007773-A1 | THIAZOLYL DIHYDRO-INDAZOLES | Boehringer Ingelheim International GmbH (DE) | 2008-12-31 | — | — | EP | disclosed |
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | US | disclosed |
| WO-2007113245-A1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007113245-A1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | MKI67, INSR, CCNT1 | P2RX4 2283/4885P2RX7 1596/4885GAA 1130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.