Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 11/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14446436 | 0.81 | P2RX4 (0.36) | P2RX4P2RX7CRHR1NPC1RAB9A | |
| SCHEMBL18930268 | 0.79 | LMNA (0.44) | LMNAMEN1GAAHPGDKMT2A | |
| SCHEMBL24938982 | 0.78 | MAPT (0.37) | NPC1RAB9ALMNAMEN1GAA | |
| SCHEMBL20046659 | 0.78 | POLB (0.35) | NPC1RAB9ALMNAGAAHPGD | |
| SCHEMBL2080439 | 0.77 | P2RX4 (0.40) | P2RX4P2RX7CRHR1NPC1RAB9A | |
| SCHEMBL13793862 | 0.76 | STAT3 (0.43) | NPC1RAB9ALMNAMEN1GAA | |
| SCHEMBL6984717 | 0.75 | CRHR1 (0.43) | CRHR1LMNAGAAHPGDKMT2A | |
| SCHEMBL16743893 | 0.75 | P2RX4 (0.46) | P2RX4P2RX7NPC1RAB9ALMNA | |
| SCHEMBL5981996 | 0.75 | KDM4E (0.51) | NPC1RAB9ALMNAMEN1GAA | |
| SCHEMBL22751309 | 0.74 | CASR (0.36) | NPC1RAB9ALMNAMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342503-B1 | ANTIDEPRESSANTS, EATING DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2002-01-29 | — | — | US | disclosed |
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| US-6103737-A | Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010506-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-20 | — | — | WO | disclosed |