Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20810003 | 0.90 | POLB (0.47) | POLBSMN1; SMN2CYP1A2KDM1AHDAC1 | |
| SCHEMBL20810180 | 0.89 | POLB (0.45) | POLBSMN1; SMN2CYP1A2KDM1AHDAC1 | |
| SCHEMBL20809981 | 0.89 | EPHX2 (0.49) | POLBSMN1; SMN2CYP1A2HSP90AA1HSP90AB1 | |
| SCHEMBL20810185 | 0.89 | HDAC1 (0.50) | POLBSMN1; SMN2CYP1A2KDM1AHDAC1 | |
| SCHEMBL20810182 | 0.88 | MAPT (0.45) | POLBSMN1; SMN2CYP1A2KDM1AHDAC1 | |
| SCHEMBL20809983 | 0.88 | POLB (0.57) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL20810004 | 0.88 | HPGDS (0.50) | POLBSMN1; SMN2CYP1A2ITKALDH1A1 | |
| SCHEMBL20810197 | 0.83 | MAPT (0.41) | POLBSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL8372297 | 0.82 | EPHX2 (0.54) | L3MBTL1EPHX2HPGDS | |
| SCHEMBL20809995 | 0.82 | RAB9A (0.47) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190077777-A1 | NICOTINIC ACID DERIVATIVES, THEIR PREPARATION AND THE USE THEREOF | XIAMEN INSTITUTE OF RARE EARTH MATERIALS (CN) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077777-A1 | NICOTINIC ACID DERIVATIVES, THEIR PREPARATION AND THE USE THEREOF | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCAR3, NAPRT | POLB 2512/4885SMN1; SMN2 2249/4885CYP1A2 1321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.