Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20814306 | 0.84 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4EPOLBHPGD | |
| SCHEMBL23431958 | 0.83 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4EPOLBHPGD | |
| SCHEMBL23405779 | 0.79 | SMN1; SMN2 (0.46) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL23405781 | 0.79 | SMN1; SMN2 (0.46) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL29103780 | 0.78 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4EPOLBHPGD | |
| SCHEMBL23431959 | 0.78 | SMN1; SMN2 (0.43) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL20814303 | 0.74 | SMN1; SMN2 (0.41) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL23431954 | 0.71 | KCNH3 (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL24054613 | 0.71 | POLB (0.42) | MEN1KMT2AALDH1A1TSHRPOLB | |
| SCHEMBL23431535 | 0.70 | GAA (0.38) | MEN1KMT2AALDH1A1KDM4EKCNH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250223267-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2025-07-10 | — | — | US | disclosed |
| US-12234211-B2 | Cycloolefin substituted heteroaromatic compounds and their use | HUTCHISON MEDIPHARMA LIMITED (CN) | 2025-02-25 | — | — | US | disclosed |
| US-20220372005-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-11-24 | — | — | US | disclosed |
| US-11414390-B2 | Cycloolefin substituted heteroaromatic compounds and their use | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-08-16 | — | — | US | disclosed |
| US-20210363115-A2 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2021-11-25 | — | — | US | disclosed |
| US-20210363115-A2 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2021-11-25 | — | — | US | disclosed |
| US-20210163426-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2021-06-03 | — | — | US | disclosed |
| US-20210163426-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2021-06-03 | — | — | US | disclosed |
| WO-2019047909-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2019-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363115-A2 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | CYP4F11, CYP11B1, CYP11B2 | WDR5 2618/4885MEN1 1163/4885KMT2A 4235/4885 |
| US-20220372005-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | CYP4F11, CYP11B1, CYP11B2 | WDR5 3017/4885MEN1 1143/4885KMT2A 4320/4885 |
| US-20250223267-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | CYP4F11, CYP11B1, CYP11B2 | WDR5 3017/4885MEN1 1143/4885KMT2A 4320/4885 |
| US-12234211-B2 | Cycloolefin substituted heteroaromatic compounds and their use | CYP4F11, CYP11B1, CYP11B2 | WDR5 3017/4885MEN1 1143/4885KMT2A 4320/4885 |
| US-11414390-B2 | Cycloolefin substituted heteroaromatic compounds and their use | CYP4F11, CYP11B1, CYP11B2 | WDR5 3003/4885MEN1 1031/4885KMT2A 4271/4885 |
| US-20210163426-A1 | CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE | CYP4F11, CYP11B1, CYP11B2 | WDR5 3003/4885MEN1 1031/4885KMT2A 4271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.