Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.54 |
| ▸ | UBE2I | P63279 | 4/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.45 |
| ▸ | APBA1 | Q02410 | 3/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17530197 | 0.85 | SERPINE1 (0.50) | SERPINE1PRMT6KMT2AMEN1ALDH1A1 | |
| SCHEMBL1015171 | 0.84 | SERPINE1 (0.75) | SERPINE1UBE2ISAE1UBA2CACNA1B | |
| SCHEMBL1015337 | 0.78 | SERPINE1 (0.62) | SERPINE1UBE2ISAE1UBA2CACNA1B | |
| SCHEMBL1016073 | 0.71 | SERPINE1 (0.72) | SERPINE1PRMT6KMT2AMEN1POLB | |
| SCHEMBL1014818 | 0.70 | SERPINE1 (0.56) | SERPINE1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL10242930 | 0.70 | PRMT6 (0.60) | PRMT6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL1014985 | 0.70 | SERPINE1 (1.00) | SERPINE1KDM4EPOLBMAPTL3MBTL1 | |
| SCHEMBL17530198 | 0.67 | SERPINE1 (0.47) | SERPINE1UBE2ISAE1UBA2CACNA1B | |
| SCHEMBL10243163 | 0.67 | PRMT6 (0.59) | PRMT6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL20814651 | 0.67 | SERPINE1 (0.56) | SERPINE1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |