Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816570 | 1.00 | PTPN1 (0.43) | PTPN1CTSLCTSSCTSBCTSK | |
| SCHEMBL20816622 | 0.97 | PTPN1 (0.44) | PTPN1CTSLCTSSCTSBCTSK | |
| SCHEMBL20816553 | 0.97 | PTPN1 (0.44) | PTPN1CTSLCTSSCTSBCTSK | |
| SCHEMBL20816725 | 0.92 | PTPN1 (0.48) | PTPN1CTSLCTSSCTSBCNR2 | |
| SCHEMBL20816638 | 0.92 | PTPN1 (0.48) | PTPN1CTSLCTSSCTSBCNR2 | |
| SCHEMBL20816635 | 0.92 | CTSL (0.49) | PTPN1CTSLCTSSCTSBMMP9 | |
| SCHEMBL20816948 | 0.92 | CTSL (0.49) | PTPN1CTSLCTSSCTSBMMP9 | |
| SCHEMBL20816687 | 0.90 | POLB (0.44) | PTPN1CTSLCTSSCTSBMMP9 | |
| SCHEMBL20816884 | 0.90 | POLB (0.44) | PTPN1CTSLCTSSCTSBMMP9 | |
| SCHEMBL20816905 | 0.89 | CTSL (0.51) | CTSLCTSSCTSBCTSKPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | Phelix Therapeutics (US) | 2019-03-21 | — | — | US | disclosed |
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | Phelix Therapeutics (US) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | CTSS, CTSB, CTSL | PTPN1 4631/4885CTSL 3/4885CTSS 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.