Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 6/20 | 0.78 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30618806 | 1.00 | ICMT (0.78) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20817570 | 0.90 | ICMT (0.63) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30618715 | 0.90 | ICMT (0.63) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20817558 | 0.88 | ICMT (0.61) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30618749 | 0.88 | ICMT (0.61) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20817566 | 0.88 | ICMT (1.00) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30618725 | 0.88 | ICMT (1.00) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20817548 | 0.88 | ICMT (0.78) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30618738 | 0.88 | ICMT (0.78) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20817543 | 0.87 | ICMT (0.76) | ICMTSCN9ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111344284-B | Compounds useful as inhibitors of isoprene cysteine carboxymethyltransferase | 新加坡科技研究局 | 2024-03-12 | — | — | CN | disclosed |
| US-11834430-B2 | Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2023-12-05 | — | — | US | disclosed |
| US-11834430-B2 | Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2023-12-05 | — | — | US | disclosed |
| US-11834430-B2 | Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2023-12-05 | — | — | US | disclosed |
| US-20210130317-A1 | Compounds Useful as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2021-05-06 | — | — | US | disclosed |
| US-20210130317-A1 | Compounds Useful as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2021-05-06 | — | — | US | disclosed |
| EP-3681878-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE | Agency for Science, Technology and Research (SG) | 2020-07-22 | — | — | EP | disclosed |
| CN-111344284-A | Compounds useful as inhibitors of isoprene cysteine carboxymethyltransferase | 新加坡科技研究局 | 2020-06-26 | — | — | CN | disclosed |
| WO-2019054944-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-03-21 | — | — | WO | disclosed |
| WO-2019054944-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130317-A1 | Compounds Useful as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase | ICMT, INMT, BHMT | ICMT 1/4885SCN9A 3500/4885CYP1A2 1135/4885 |
| US-11834430-B2 | Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase | ICMT, INMT, BHMT | ICMT 1/4885SCN9A 3500/4885CYP1A2 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.