Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 3/20 | 0.33 |
| ▸ | CES1 | P23141 | 3/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PKLR | P30613 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11987671 | 0.87 | MEN1 (0.42) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL15614299 | 0.82 | GABRA1 (0.40) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL95708 | 0.79 | ERN1 (0.50) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL18797733 | 0.78 | ALDH1A1 (0.35) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL16634677 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ATDP1POLB | |
| SCHEMBL18570190 | 0.77 | ERN1 (0.35) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL652253 | 0.71 | ERN1 (0.59) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL4743962 | 0.71 | ERN1 (0.44) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL29602790 | 0.71 | ERN1 (0.44) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL16793363 | 0.71 | DRD1 (0.46) | ERN1ALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941475-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| WO-2020191056-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
| EP-3684364-A2 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2020-07-29 | — | — | EP | disclosed |
| WO-2019055966-A2 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-03-21 | — | — | WO | disclosed |