Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 10/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 10/20 | 0.53 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165812 | 0.76 | CHRNB4 (0.87) | CHRNB4CHRNA3NISCHCYP1A2ALDH1A1 | |
| SCHEMBL12363751 | 0.74 | NPC1 (0.59) | CHRNB4CHRNA3CYP1A2ALDH1A1THRB | |
| SCHEMBL14047263 | 0.72 | CHRNB4 (0.54) | CHRNB4CHRNA3CYP1A2ALDH1A1THRB | |
| SCHEMBL1977761 | 0.72 | CHRNB4 (0.54) | CHRNB4CHRNA3CYP1A2ALDH1A1THRB | |
| SCHEMBL31578497 | 0.71 | MAOA (0.43) | NISCHCYP1A2ALDH1A1GSTP1ESR1 | |
| SCHEMBL19844058 | 0.71 | NISCH (0.43) | NISCHCYP1A2GSTP1ESR1ESR2 | |
| SCHEMBL28652255 | 0.71 | NQO1 (0.42) | NISCHCYP1A2ALDH1A1CYP2C19GSTP1 | |
| SCHEMBL6558703 | 0.70 | CHRNB4 (0.90) | CHRNB4CHRNA3NISCHCYP1A2ALDH1A1 | |
| SCHEMBL433117 | 0.70 | CHRNB4 (0.90) | CHRNB4CHRNA3NISCHCYP1A2ALDH1A1 | |
| SCHEMBL6796957 | 0.70 | CHRNA7 (0.54) | CHRNB4CHRNA3NISCHCYP1A2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109988091-B | Preparation method of imine compound | 苏州大学 | 2022-03-18 | — | — | CN | disclosed |
| US-11161863-B2 | Chiral catalyst and method for asymmetric reduction of an imine | DALHOUSIE UNIVERSITY (CA) | 2021-11-02 | — | — | US | disclosed |
| US-11161863-B2 | Chiral catalyst and method for asymmetric reduction of an imine | DALHOUSIE UNIVERSITY (CA) | 2021-11-02 | — | — | US | disclosed |
| US-20200255463-A1 | CHIRAL CATALYST AND METHOD FOR ASYMMETRIC REDUCTION OF AN IMINE | DALHOUSIE UNIVERSITY (CA) | 2020-08-13 | — | — | US | disclosed |
| US-20200255463-A1 | CHIRAL CATALYST AND METHOD FOR ASYMMETRIC REDUCTION OF AN IMINE | DALHOUSIE UNIVERSITY (CA) | 2020-08-13 | — | — | US | disclosed |
| WO-2019051585-A1 | CHIRAL CATALYST AND METHOD FOR ASYMMETRIC REDUCTION OF AN IMINE | DALHOUSIE UNIVERSITY (CA) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255463-A1 | CHIRAL CATALYST AND METHOD FOR ASYMMETRIC REDUCTION OF AN IMINE | C1R, C5, C1S | CHRNB4 2102/4885CHRNA3 1979/4885NISCH 257/4885 |
| US-11161863-B2 | Chiral catalyst and method for asymmetric reduction of an imine | C1R, C5, C1S | CHRNB4 2102/4885CHRNA3 1979/4885NISCH 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.