Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 9/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.54 |
| ▸ | AHR | P35869 | 3/20 | 0.48 |
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15665457 | 0.78 | CHRNB4 (0.55) | CHRNB4CHRNA3PGRALDH1A1CYP1A2 | |
| SCHEMBL17398232 | 0.76 | CHRNB4 (0.90) | CHRNB4CHRNA3PGRALDH1A1CYP1A2 | |
| SCHEMBL18985115 | 0.75 | CHRNB4 (0.67) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL14047263 | 0.73 | CHRNB4 (0.54) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL30022452 | 0.73 | MAOA (0.45) | AHRALDH1A1CYP1A2HPGDSLC6A3 | |
| SCHEMBL24322363 | 0.72 | ALDH1A1 (0.51) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL20819791 | 0.72 | CHRNB4 (0.53) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL24363905 | 0.70 | AHR (0.41) | AHRPGRALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4693339 | 0.69 | CHRNB4 (0.55) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL24414772 | 0.69 | CHRNB4 (0.55) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102112473-B | Pyrrolidinyl-alkyl-amide derivatives, process for their preparation and their therapeutic use as CCR3 receptor ligands | SANOFI AVENTIS | 2014-08-20 | — | — | CN | disclosed |
| EP-2318402-B1 | Pyrrolidinyl-alkyl-amide derivatives their preparation and their therapeutic application as CCR3 receptor ligands | SANOFI SA (FR) | 2014-04-30 | — | — | EP | disclosed |
| US-8420636-B2 | Pyrrolidinyl-alkyl-amide derivatives, their preparation, and their therapeutic application as CCR3 receptor ligands | SANOFI (FR) | 2013-04-16 | — | — | US | disclosed |
| US-20110144104-A1 | PYRROLIDINYL-ALKYL-AMIDE DERIVATIVES, THEIR PREPARATION, AND THEIR THERAPEUTIC APPLICATION AS CCR3 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144104-A1 | PYRROLIDINYL-ALKYL-AMIDE DERIVATIVES, THEIR PREPARATION, AND THEIR THERAPEUTIC APPLICATION AS CCR3 RECEPTOR LIGANDS | CCR3, CCR1, CCR4 | CHRNB4 1176/4885CHRNA3 167/4885AHR 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.