SCHEMBL20829145

SCHEMBL20829145

CC1(N)C=CC=C(c2nc(-c3ccccc3)cc(-c3ccccc3)n2)C=C1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.41
ADORA1 P30542 2/20 0.41
MEN1 O00255 10/20 0.41
KMT2A Q03164 10/20 0.41
MAPT P10636 6/20 0.41
ALDH1A1 P00352 5/20 0.41
HPGD P15428 5/20 0.41
KDM4E B2RXH2 3/20 0.39
LMNA P02545 2/20 0.39
AGTR1 P30556 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
TSHR P16473 1/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
NTSR1 P30989 1/20 0.37
GLA P06280 1/20 0.36
CYP1A1 P04798 1/20 0.35
CYP1B1 Q16678 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20829147 0.92 MEN1 (0.45) ADORA2AADORA1MEN1KMT2AMAPT
SCHEMBL20829146 0.89 ADORA2A (0.38) ADORA2AADORA1MEN1KMT2AMAPT
SCHEMBL21972969 0.88 L3MBTL1 (0.41) ADORA2AADORA1MEN1KMT2AMAPT
SCHEMBL20829149 0.86 MEN1 (0.40) ADORA2AADORA1MEN1KMT2AMAPT
SCHEMBL21972972 0.85 MEN1 (0.40) ADORA2AADORA1MEN1KMT2AMAPT
SCHEMBL21233511 0.83 KDM1A (0.31)
SCHEMBL20829144 0.82 RAB9A (0.43) ADORA1MEN1KMT2AMAPTALDH1A1
SCHEMBL21973501 0.79 IKBKB (0.33)
SCHEMBL22212825 0.73 KMT2A (0.40) ADORA2AADORA1MEN1KMT2AMAPT
SCHEMBL25923595 0.73 L3MBTL1 (0.43) ADORA2AADORA1MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3197982-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2020-05-06 EP disclosed
WO-2019052933-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2019-03-21 WO disclosed