Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.61 |
| ▸ | IL1RN | P18510 | 5/20 | 0.61 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.59 |
| ▸ | ANPEP | P15144 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30374944 | 1.00 | ERAP2 (0.61) | ERAP2IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL20829978 | 0.96 | OPRK1 (0.62) | ERAP2IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL30800609 | 0.93 | KMT2A (0.66) | ERAP2IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL20829913 | 0.93 | KMT2A (0.66) | ERAP2IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL27785991 | 0.91 | ERAP1 (0.64) | ERAP2IL1RNERAP1 | |
| SCHEMBL27785998 | 0.91 | ERAP1 (0.64) | ERAP2IL1RNERAP1 | |
| SCHEMBL11660007 | 0.89 | IL1RN (0.61) | ERAP2IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL11853819 | 0.89 | KMT2A (0.67) | KMT2AMEN1KDM4ELMNAMPO | |
| SCHEMBL10448989 | 0.89 | KMT2A (0.67) | KMT2AMEN1KDM4ELMNAMPO | |
| SCHEMBL3361183 | 0.89 | KMT2A (0.67) | KMT2AMEN1KDM4ELMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224609-B2 | Mithramycin derivatives having increased selectivity and anti-cancer activity | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2022-01-18 | — | — | US | disclosed |
| US-20190083519-A1 | MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY | UNITED STATES GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11224609-B2 | Mithramycin derivatives having increased selectivity and anti-cancer activity | TFAM, ELF3, TEAD4 | ERAP2 1528/4885IL1RN 2638/4885ERAP1 685/4885 |
| US-20190083519-A1 | MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY | TFAM, ELF3, TEAD4 | ERAP2 1528/4885IL1RN 2638/4885ERAP1 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.