Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.41 |
| ▸ | KDM5A | P29375 | 4/20 | 0.41 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20819226 | 0.78 | KDM4E (0.52) | KDM4CCLK4GAAKDM4EKDM4A | |
| SCHEMBL20830294 | 0.75 | NOX4 (0.47) | NOX4NOX1ALDH1A1KDM4CKDM5B | |
| SCHEMBL20830149 | 0.74 | KDM4C (0.51) | NOX4NOX1ALDH1A1KDM4CKDM5B | |
| SCHEMBL20830295 | 0.72 | RAB9A (0.46) | NOX4NOX1ALDH1A1KDM4CKDM5B | |
| SCHEMBL20830151 | 0.71 | NOX4 (0.48) | NOX4NOX1KDM4CKDM5BKDM5A | |
| SCHEMBL8018020 | 0.70 | KDM4C (0.53) | NOX4NOX1KDM4CKDM5BKDM5A | |
| SCHEMBL20830327 | 0.70 | KDM4C (0.46) | NOX4NOX1ALDH1A1KDM4CKDM5B | |
| SCHEMBL20830287 | 0.68 | KDM4E (0.55) | ALDH1A1KDM4CCLK4GAAKDM4E | |
| SCHEMBL2995142 | 0.68 | L3MBTL1 (0.48) | ALDH1A1ABL1GAAL3MBTL1 | |
| SCHEMBL29620897 | 0.68 | L3MBTL1 (0.48) | ALDH1A1ABL1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
| WO-2019055540-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. SHAW RESEARCH, LLC (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | KRAS, NRAS, HRAS | NOX4 1655/4885NOX1 729/4885ALDH1A1 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.