Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RGS12 | O14924 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16965549 | 0.88 | KMT2A (0.61) | KMT2AMEN1KDM4EHPGDMAPT | |
| SCHEMBL20830735 | 0.87 | MEN1 (0.47) | KMT2AMEN1KDM4EHPGDMAPT | |
| SCHEMBL20830510 | 0.85 | APAF1 (0.45) | KMT2AMEN1KDM4EHPGDMAPT | |
| SCHEMBL20830399 | 0.81 | CA12 (0.47) | KMT2AMEN1MAPTLMNARGS12 | |
| SCHEMBL20830748 | 0.81 | MEN1 (0.46) | KMT2AMEN1MAPTLMNARGS12 | |
| SCHEMBL20830398 | 0.81 | MEN1 (0.46) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL20814679 | 0.81 | CYP1A2 (0.52) | KMT2AMEN1KDM4EHPGDMAPT | |
| SCHEMBL16964861 | 0.81 | CA1 (0.47) | KMT2AMEN1MAPTLMNARGS12 | |
| SCHEMBL16965659 | 0.78 | CLTC (0.43) | KMT2AMEN1KDM4EHPGDMAPT | |
| SCHEMBL16965144 | 0.78 | KDM4E (0.55) | KMT2AMEN1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900239-B1 | DIHYDRO-6-AZAPHENALENE DERIVATIVES FOR THE TREATMENT OF CNS, OCULAR DISEASES AND RELATED DISORDERS | WARNER BABCOCK INST FOR GREEN CHEMISTRY LLC (US) | 2019-03-20 | — | — | EP | disclosed |