Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30587758 | 0.85 | MAPT (0.37) | MAPTALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL523318 | 0.79 | MAPT (0.41) | MAPTALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL16322053 | 0.79 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4EPOLBTSHR | |
| Acetic Acid SCHEMBL28452088 | 0.79 | MAPT (0.38) | MAPTALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL18105691 | 0.78 | MAPT (0.36) | MAPTALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL6510812 | 0.76 | GRM8 (0.31) | GRM8GRM6GRM2GRM3 | |
| SCHEMBL855129 | 0.75 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL6505565 | 0.74 | GRM8 (0.33) | GRM8GRM6GRM2GRM3 | |
| SCHEMBL8675518 | 0.74 | MAPT (0.43) | MAPTALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL6502942 | 0.73 | GRM5 (0.34) | GRM8GRM6GRM2GRM3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906505-B2 | Apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100249133-A1 | APOPTOSIS PROMOTERS | Abbott Laboraoties | 2010-09-30 | — | — | US | disclosed |
| US-7375102-B2 | Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use | AMGEN SF, LLC (US) | 2008-05-20 | — | — | US | disclosed |
| EP-1765818-A1 | TETRAHYDROQUINAZOLIN-4(3H)-ONE-RELATED AND TETRAHYDROPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE-RELATED COMPOUNDS, COMPOSITIONS AND METHODS FOR THEIR USE | Amgen SF LLC (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060069106-A1 | Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use | AMGEN SF, LLC | 2006-03-30 | — | — | US | disclosed |
| WO-2006004925-A1 | TETRAHYDROQUINAZOLIN-4(3H)-ONE-RELATED AND TETRAHYDROPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE-RELATED COMPOUNDS, COMPOSITIONS AND METHODS FOR THEIR USE | AMGEN SF, LLC (US) | 2006-01-12 | — | — | WO | disclosed |
| CN-1059072-A | Contain the plant protection preparation of different azoles quinoline or isothiazoline and new different azoles quinoline class and isothiazoline compounds | HOECHST AG (DE) | 1992-03-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249133-A1 | APOPTOSIS PROMOTERS | BAX, API5, BCL2 | MAPT 4226/4885ALDH1A1 3367/4885KDM4E 3431/4885 |
| US-20060069106-A1 | Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use | IFNG, IRF3, TBXA2R | MAPT 2881/4885ALDH1A1 1182/4885KDM4E 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.