Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857663 | 0.88 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL2456370 | 0.84 | MAPT (0.42) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL15416529 | 0.84 | ALDH1A1 (0.45) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL12336797 | 0.82 | MAPT (0.40) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL11527194 | 0.82 | ALDH1A1 (0.35) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL11527188 | 0.82 | ALDH1A1 (0.35) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL523318 | 0.81 | MAPT (0.41) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL21733525 | 0.80 | TLR4 (0.45) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL184048 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL1338366 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MAPTKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117229208-B | Condensed ring compound, preparation method and medical application thereof | 上海泽德曼医药科技有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-117229208-A | Condensed ring compound, preparation method and medical application thereof | 上海泽德曼医药科技有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-108203382-B | Novel organoleptic compounds | 国际香料和香精公司 | 2022-03-04 | — | — | CN | disclosed |
| US-10435645-B2 | Organoleptic compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-10435645-B2 | Organoleptic compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2019-10-08 | — | — | US | disclosed |
| EP-3339278-B1 | NOVEL ORGANOLEPTIC COMPOUNDS | INT FLAVORS & FRAGRANCES INC (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-3339278-B1 | NOVEL ORGANOLEPTIC COMPOUNDS | INT FLAVORS & FRAGRANCES INC (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-3339278-A1 | NOVEL ORGANOLEPTIC COMPOUNDS | International Flavors & Fragrances Inc. (US) | 2018-06-27 | — | — | EP | disclosed |
| US-20180171263-A1 | NOVEL ORGANOLEPTIC COMPOUNDS | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2018-06-21 | — | — | US | disclosed |
| US-20180171263-A1 | NOVEL ORGANOLEPTIC COMPOUNDS | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2018-06-21 | — | — | US | disclosed |
| US-20140107100-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8648066-B2 | Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture | EXELIXIS, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| CN-103459384-A | Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture | EXELIXIS INC | 2013-12-18 | — | — | CN | disclosed |
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | ALDH1A1 3395/4885MAPT 1278/4885KDM4E 610/4885 |
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | HTT, HMOX1, SNCA | ALDH1A1 1088/4885MAPT 29/4885KDM4E 2960/4885 |
| US-20180171263-A1 | NOVEL ORGANOLEPTIC COMPOUNDS | TRPA1, TRPV1, TRPV5 | ALDH1A1 143/4885MAPT 2278/4885KDM4E 1150/4885 |
| US-20140107100-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | ALDH1A1 3533/4885MAPT 1136/4885KDM4E 361/4885 |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | ALDH1A1 3049/4885MAPT 1639/4885KDM4E 760/4885 |
| US-10435645-B2 | Organoleptic compounds | TRPA1, TRPV1, TRPV5 | ALDH1A1 141/4885MAPT 2357/4885KDM4E 1502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.