Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 10/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.63 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.63 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497717 | 0.88 | FTO (0.66) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL14769914 | 0.88 | FTO (0.63) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL29838678 | 0.85 | FTO (0.69) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL29996062 | 0.85 | FTO (0.69) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL20095 | 0.85 | FTO (0.69) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL29358729 | 0.85 | FTO (0.69) | FTOMAPTHPGDMEN1HTT | |
| Water SCHEMBL25247555 | 0.84 | FTO (0.67) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL2877099 | 0.84 | FTO (0.67) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL15059064 | 0.84 | FTO (0.70) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL12275226 | 0.84 | FTO (0.72) | FTOMAPTHPGDMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493855-A1 | COMPOSITIONS AND METHODS FOR DETECTING CANCER CELLS IN A TISSUE SAMPLE | ISI Life Sciences, Inc. (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018026965-A1 | COMPOSITIONS AND METHODS FOR DETECTING CANCER CELLS IN A TISSUE SAMPLE | ISI LIFE SCIENCES, INC. (US) | 2018-02-08 | — | — | WO | disclosed |
| US-8163788-B2 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT BONN (DE) | 2012-04-24 | — | — | US | disclosed |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1811997-A2 | LOW-MOLECULAR INHIBITORS OF CYTOHESIN-FAMILY GUANINE NUCLEOTIDE EXCHANGE FACTORS | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006053903-A2 | LOW-MOLECULAR INHIBITORS OF CYTOHESIN-FAMILY GUANINE NUCLEOTIDE EXCHANGE FACTORS | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT (DE) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | CYTH2, CYTH3, ENTPD5 | FTO 4583/4885MAPT 4844/4885HPGD 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.