Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20835675 | 0.86 | CALCRL (0.47) | RIPK1PDE5AHPGDHTTJAK2 | |
| SCHEMBL14563156 | 0.83 | TRPA1 (0.50) | RIPK1TRPA1 | |
| SCHEMBL28528295 | 0.83 | RIPK1 (0.50) | RIPK1PDE5ATRPA1JAK2NTRK1 | |
| SCHEMBL4097098 | 0.82 | FFAR2 (0.45) | RIPK1TRPA1 | |
| SCHEMBL20835825 | 0.81 | RIPK1 (0.44) | RIPK1PDE5AHPGDHTTJAK2 | |
| SCHEMBL20835925 | 0.79 | CALCRL (0.49) | RIPK1PDE5ACALCRL | |
| SCHEMBL20835556 | 0.78 | RIPK1 (0.47) | RIPK1PDE5AHPGDHTTDRD4 | |
| SCHEMBL21797965 | 0.78 | RIPK1 (0.46) | RIPK1PDE5ATRPA1DRD4TDP1 | |
| SCHEMBL20835378 | 0.77 | RIPK1 (0.46) | RIPK1PDE5AHPGDHTTDRD4 | |
| SCHEMBL20835548 | 0.76 | RIPK1 (0.45) | RIPK1PDE5AHPGDHTTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995084-B2 | Pyrrolidine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2020-09-24 | — | — | US | disclosed |
| EP-3459941-A1 | PYRROLIDINE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2019-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | CALCRL, NPY1R, GRPR | RIPK1 1917/4885PDE5A 439/4885TRPA1 169/4885 |
| US-10995084-B2 | Pyrrolidine derivative | CALCRL, NPY1R, GRPR | RIPK1 1917/4885PDE5A 439/4885TRPA1 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.