Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 7/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 7/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.39 |
| ▸ | CHRNG | P07510 | 5/20 | 0.39 |
| ▸ | CHRND | Q07001 | 5/20 | 0.39 |
| ▸ | ICMT | O60725 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250979 | 0.84 | SLC6A3 (0.41) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNB1 | |
| SCHEMBL6158800 | 0.82 | TSHR (0.43) | — | |
| SCHEMBL20835743 | 0.81 | HSD11B1 (0.40) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNB1 | |
| SCHEMBL20835927 | 0.79 | SLC6A3 (0.37) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNB1 | |
| SCHEMBL11541948 | 0.79 | HTR2C (0.42) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNB1 | |
| SCHEMBL4613715 | 0.77 | TSHR (0.42) | — | |
| SCHEMBL27590402 | 0.71 | OPRM1 (0.38) | — | |
| SCHEMBL9341769 | 0.71 | TSHR (0.45) | — | |
| SCHEMBL13897208 | 0.69 | SLC6A3 (0.48) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNB1 | |
| SCHEMBL20835454 | 0.69 | DPP4 (0.33) | SLC6A3SLC6A2SLC6A4CHRNA1CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995084-B2 | Pyrrolidine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| CN-109476639-B | Pyrrolidine derivatives | 橘生药品工业股份有限公司 | 2021-02-26 | — | — | CN | disclosed |
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2020-09-24 | — | — | US | disclosed |
| WO-2019112024-A1 | PYRROLIDINE COMPOUND | キッセイ薬品工業株式会社 | 2019-06-13 | — | — | WO | disclosed |
| EP-3459941-A1 | PYRROLIDINE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2019-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299273-A1 | PYRROLIDINE DERIVATIVE | CALCRL, NPY1R, GRPR | SLC6A3 648/4885SLC6A2 820/4885SLC6A4 448/4885 |
| US-10995084-B2 | Pyrrolidine derivative | CALCRL, NPY1R, GRPR | SLC6A3 648/4885SLC6A2 820/4885SLC6A4 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.