Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20835964 | 0.82 | GPR119 (0.49) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL1727311 | 0.79 | KDM4E (0.46) | TRPV3JAK2JAK1TYK2JAK3 | |
| SCHEMBL3572206 | 0.74 | MAPK7 (0.49) | JAK2JAK1TYK2JAK3GPR119 | |
| SCHEMBL14240648 | 0.72 | TRPV3 (0.51) | TRPV3ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL12127691 | 0.72 | JAK1 (0.49) | TRPV3JAK2JAK1TYK2JAK3 | |
| SCHEMBL23923085 | 0.71 | GPR119 (0.47) | GPR119 | |
| SCHEMBL23316236 | 0.71 | PTPN2 (0.56) | ALDH1A1MAPTMAPK1L3MBTL1HTT | |
| SCHEMBL2063726 | 0.70 | THRB (0.44) | TRPV3CNR1MAPTHTTKDM4E | |
| SCHEMBL12127688 | 0.69 | SCN9A (0.52) | TRPV3JAK2JAK1TYK2JAK3 | |
| SCHEMBL29364363 | 0.69 | BTK (0.49) | JAK1ALDH1A1MAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459953-B1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | TAIHO PHARMACEUTICAL CO LTD (JP) | 2021-06-30 | — | — | EP | disclosed |
| CN-109153681-B | Novel 5H-pyrrolo [2,3-d ] pyrimidin-6 (7H) -one derivatives | 大鹏药品工业株式会社 | 2021-06-04 | — | — | CN | disclosed |
| US-20190292190-A1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2019-09-26 | — | — | US | disclosed |
| EP-3459953-A1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | Taiho Pharmaceutical Co., Ltd. (JP) | 2019-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292190-A1 | NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE | RPS6KA1, RPS6KA3, MAPK9 | TRPV3 3806/4885JAK2 150/4885JAK1 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.