Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407236 | 0.72 | ALDH1A1 (0.49) | HTTC5AR1ALDH1A1MEN1KMT2A | |
| SCHEMBL20836411 | 0.71 | C5AR1 (0.41) | HTTC5AR1ALDH1A1MEN1KMT2A | |
| SCHEMBL8499455 | 0.71 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL997586 | 0.69 | P2RX3 (0.50) | — | |
| SCHEMBL20836477 | 0.68 | GRM7 (0.46) | HTTPARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL31483708 | 0.68 | GRM7 (0.46) | HTTPARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL4864780 | 0.68 | TRPV1 (0.40) | — | |
| SCHEMBL5430634 | 0.68 | ADRB1 (0.50) | PARP1ALDH1A1MAPT | |
| SCHEMBL22512460 | 0.68 | ALDH1A1 (0.41) | HTTPARP1ALDH1A1MEN1KMT2A | |
| SCHEMBL5431075 | 0.67 | SCN9A (0.44) | HTTPARP1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459939-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS MODULATORS OF MGLUR7 | Pragma Therapeutics (FR) | 2019-03-27 | — | — | EP | disclosed |