Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288141 | 0.84 | KDM4E (0.78) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL17374796 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1GAATRPM8RAB9A | |
| SCHEMBL17374827 | 0.82 | TRPM8 (0.58) | KDM4EALDH1A1GAATRPM8RAB9A | |
| SCHEMBL17374800 | 0.81 | TRPM8 (0.57) | KDM4EALDH1A1GAATRPM8RAB9A | |
| SCHEMBL17374817 | 0.79 | TRPM8 (0.64) | KDM4EALDH1A1GAATRPM8MAPT | |
| SCHEMBL9629249 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL3418775 | 0.75 | KDM4E (1.00) | KDM4EALDH1A1GAAKMT2ARAB9A | |
| SCHEMBL3059795 | 0.74 | KDM4E (0.76) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL23792544 | 0.71 | KDM4E (0.73) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL298290 | 0.71 | KDM4E (1.00) | KDM4EALDH1A1GAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3157918-B1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA. | DOMPE FARM SPA (IT) | 2019-03-27 | — | — | EP | claimed |