Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | GAA | P10253 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059795 | 0.84 | KDM4E (0.76) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL288141 | 0.82 | KDM4E (0.78) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3418775 | 0.82 | KDM4E (1.00) | KDM4EGAAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL290132 | 0.80 | KDM4E (1.00) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| Decane SCHEMBL28453162 | 0.79 | KDM4E (0.64) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL290222 | 0.77 | KDM4E (0.64) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL288846 | 0.75 | KDM4E (0.84) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4167344 | 0.74 | ALDH1A1 (0.67) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14800165 | 0.73 | GAA (1.00) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL289139 | 0.73 | KDM4E (0.86) | KDM4EGAAALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | claimed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | claimed |
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |