Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CLTC | Q00610 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19330079 | 1.00 | CASP3 (0.40) | CASP3MMP2MMP9PTGS2HSD11B1 | |
| SCHEMBL20851037 | 0.88 | CASP3 (0.36) | CASP3MMP2MMP9PTGS2HSD11B1 | |
| SCHEMBL19329978 | 0.84 | ALDH1A1 (0.48) | CASP3MMP2MMP9KMT2AALDH1A1 | |
| SCHEMBL20838349 | 0.84 | ALDH1A1 (0.48) | CASP3MMP2MMP9KMT2AALDH1A1 | |
| SCHEMBL20838423 | 0.82 | MEN1 (0.46) | CASP3MMP2MMP9KMT2AALDH1A1 | |
| SCHEMBL29881198 | 0.82 | MEN1 (0.46) | CASP3MMP2MMP9KMT2AALDH1A1 | |
| SCHEMBL20838424 | 0.82 | MEN1 (0.46) | CASP3MMP2MMP9KMT2AALDH1A1 | |
| SCHEMBL19346594 | 0.82 | MAPT (0.44) | CASP3KMT2AALDH1A1POLBPKM | |
| SCHEMBL22723198 | 0.82 | MAPT (0.44) | CASP3KMT2AALDH1A1POLBPKM | |
| SCHEMBL20838412 | 0.79 | PTGDR2 (0.43) | PTGS2HSD11B1ALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11453677-B2 | Tricyclic compounds useful to treat orthomyxovirus infections | NOVARTIS AG (CH) | 2022-09-27 | — | — | US | disclosed |
| EP-3426656-B1 | TRICYCLIC COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2021-05-12 | — | — | EP | disclosed |
| US-10858366-B2 | Tricyclic compounds useful to treat orthomyxovirus infections | NOVARTIS AG (CH) | 2020-12-08 | — | — | US | disclosed |
| US-20200347072-A1 | Tricyclic Compounds Useful to Treat Orthomyxovirus Infections | NOVARTIS AG (CH) | 2020-11-05 | — | — | US | disclosed |
| US-20190092780-A1 | TRICYCLIC COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2019-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858366-B2 | Tricyclic compounds useful to treat orthomyxovirus infections | ZC3HAV1, OTC, THOP1 | CASP3 3073/4885MMP2 931/4885MMP9 3731/4885 |
| US-20200347072-A1 | Tricyclic Compounds Useful to Treat Orthomyxovirus Infections | ZC3HAV1, OTC, THOP1 | CASP3 2751/4885MMP2 883/4885MMP9 3738/4885 |
| US-11453677-B2 | Tricyclic compounds useful to treat orthomyxovirus infections | ZC3HAV1, OTC, THOP1 | CASP3 2751/4885MMP2 883/4885MMP9 3738/4885 |
| US-20190092780-A1 | TRICYCLIC COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | ZC3HAV1, OTC, THOP1 | CASP3 3073/4885MMP2 931/4885MMP9 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.