Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | RARA | P10276 | 2/20 | 0.42 |
| ▸ | RARG | P13631 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20839505 | 0.87 | MEN1 (0.48) | CA12CA9ALOX5LMNANR1H4 | |
| SCHEMBL31191924 | 0.82 | ALOX5 (0.45) | ALOX5NR1H4MAOBMAOARARA | |
| SCHEMBL29495392 | 0.81 | MEN1 (0.51) | CA12CA9ALOX5CCR2LMNA | |
| SCHEMBL1504097 | 0.81 | MEN1 (0.51) | CA12CA9ALOX5CCR2LMNA | |
| SCHEMBL2818307 | 0.81 | CCR2 (0.45) | ALOX5CCR2LMNANR1H4MAOB | |
| SCHEMBL432850 | 0.80 | ALOX5 (0.71) | CA12CA9ALOX5NR1H4MAOB | |
| SCHEMBL13366367 | 0.80 | ALOX5 (0.44) | ALOX5NR1H4MAOBMAOARARA | |
| SCHEMBL3499773 | 0.79 | CCR5 (0.53) | ALOX5LMNAMAOBMAOAHTT | |
| SCHEMBL212724 | 0.76 | ALOX5 (0.64) | ALOX5MAOBMAOAMEN1KMT2A | |
| SCHEMBL16397645 | 0.76 | ALOX5 (0.64) | ALOX5MAOBMAOAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057969-A1 | DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES | Johann Wolfgang Goethe-Universität (DE) | 2019-03-28 | — | — | WO | disclosed |