Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25858277 | 0.81 | MAPT (0.53) | KDM4EALDH1A1TDP1MAPTSMN1; SMN2 | |
| SCHEMBL16622970 | 0.81 | MAPT (0.53) | KDM4EALDH1A1TDP1MAPTSMN1; SMN2 | |
| SCHEMBL941201 | 0.81 | TDP1 (0.66) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL22604524 | 0.78 | MAPT (0.49) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL17286565 | 0.76 | TDP1 (0.53) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL6557649 | 0.73 | MAOB (0.57) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| Dimethylamine SCHEMBL6784757 | 0.73 | MAPT (0.59) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL15634869 | 0.73 | ESRRG (0.45) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL7767418 | 0.73 | HTR1B (0.64) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL6852447 | 0.72 | TDP1 (0.50) | KDM4EALDH1A1DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057757-A1 | 1,3-DIHYDROIMIDAZO[4,5-C]CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-03-28 | — | — | WO | disclosed |