⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29350099 | 0.69 | NPC1 (0.65) | — | |
| Quinoline SCHEMBL29822171 | 0.69 | ALDH1A1 (1.00) | — | |
| Quinoline SCHEMBL1270969 | 0.69 | ALDH1A1 (1.00) | — | |
| Quinoline SCHEMBL32661377 | 0.69 | ALDH1A1 (1.00) | — | |
| Quinoline SCHEMBL29349552 | 0.69 | ALDH1A1 (1.00) | — | |
| Quinoline SCHEMBL2774 | 0.69 | ALDH1A1 (1.00) | — | |
| SCHEMBL150476 | 0.69 | NPC1 (0.65) | — | |
| Quinoline SCHEMBL23202414 | 0.67 | ALDH1A1 (0.94) | — | |
| Quinoline SCHEMBL18062510 | 0.67 | ALDH1A1 (0.94) | — | |
| Quinoline SCHEMBL6381814 | 0.67 | ALDH1A1 (0.94) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 191 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935824-B2 | Ethylenediamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-03 | — | — | US | claimed |
| EP-0003645-B1 | PROCESS FOR THE PREPARATION OF AROMATIC (B)-FUSED PYRIDINES AND NOVEL THIENO(B)PYRIDINES | CRODA SYNTHETIC CHEMICALS LIMITED (GB) | 1982-05-05 | — | — | EP | claimed |
| EP-0003645-A1 | Process for the preparation of aromatic (b)-fused pyridines and novel thieno(b)pyridines | CRODA SYNTHETIC CHEMICALS LIMITED (GB) | 1979-08-22 | — | — | EP | claimed |
| EP-3611165-B1 | PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT | MITSUI CHEMICALS CROP & LIFE SOLUTIONS INC (JP) | 2023-08-16 | — | — | EP | disclosed |
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |
| US-20220064197-A1 | PHOSPHINE OXIDE GROUP-CONTAINED TRANSITION METAL COMPLEX, AND POLYMER, MIXTURE, COMPOSITION, AND ORGANIC ELECTRONIC DEVICE THEREOF | GUANGZHOU CHINARAY OPTOELECTRONIC MATERIALS LTD. (CN) | 2022-03-03 | — | — | US | disclosed |
| US-11197857-B2 | Combination therapy | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-12-14 | — | — | US | disclosed |
| US-20210106580-A1 | COMBINATION THERAPY | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-15 | — | — | US | disclosed |
| US-20210078951-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. | 2021-03-18 | — | — | US | disclosed |
| WO-2021025407-A1 | OXO-PYRIDINE FUSION RING DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 웰마커바이오 주식회사 | 2021-02-11 | — | — | WO | disclosed |
| EP-0209977-A2 | Thienopyridones, processes and intermediates for their preparation and pharmaceutical compositions containing them | The Boots Company PLC (GB) | 1987-01-28 | — | — | EP | disclosed |
| US-4577014-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1986-03-18 | — | — | US | disclosed |
| EP-0135142-A2 | Cephalosporin derivatives and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-03-27 | — | — | EP | disclosed |
| US-4501739-A | BACTERICIDES, ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1985-02-26 | — | — | US | disclosed |
| EP-0125576-A2 | Process for the preparation of cephalosporins | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-11-21 | — | — | EP | disclosed |
| EP-0124889-A2 | Process for the preparation of cephalosporins | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-11-14 | — | — | EP | disclosed |
| US-4375544-A | Fused pyridines | CRODA SYNTHETIC CHEMICALS LIMITED (GB) | 1983-03-01 | — | — | US | disclosed |
| EP-0003645-B1 | PROCESS FOR THE PREPARATION OF AROMATIC (B)-FUSED PYRIDINES AND NOVEL THIENO(B)PYRIDINES | CRODA SYNTHETIC CHEMICALS LIMITED (GB) | 1982-05-05 | — | — | EP | disclosed |
| EP-0003645-A1 | Process for the preparation of aromatic (b)-fused pyridines and novel thieno(b)pyridines | CRODA SYNTHETIC CHEMICALS LIMITED (GB) | 1979-08-22 | — | — | EP | disclosed |