Quinoline

Quinoline

SCHEMBL2774

c1ccc2ncccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
NPC1 O15118 2/20 0.58
POLB P06746 1/20 0.58
RAB9A P51151 1/20 0.58
CYP3A4 P08684 3/20 0.56
MAPT P10636 5/20 0.54
HTT P42858 3/20 0.54
KDM4E B2RXH2 3/20 0.54
CASP1 P29466 2/20 0.54
TP53 P04637 2/20 0.54
HSP90AA1 P07900 2/20 0.54
TSHR P16473 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
MEN1 O00255 1/20 0.54
CASP7 P55210 1/20 0.54
KMT2A Q03164 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2C19 P33261 1/20 0.54
NR4A2 P43354 1/20 0.54
HSP90AB1 P08238 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL32661377 1.00 ALDH1A1 (1.00) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL29349552 1.00 ALDH1A1 (1.00) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL1270969 1.00 ALDH1A1 (1.00) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL29822171 1.00 ALDH1A1 (1.00) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL23202414 0.97 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL5422407 0.97 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL4955314 0.97 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL18062510 0.97 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL20969722 0.97 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9ACYP3A4
Quinoline SCHEMBL1935828 0.97 ALDH1A1 (0.94) ALDH1A1NPC1POLBRAB9ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 432752 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6433115-B1 None US claimed
US-6362369-B1 None US claimed
CN-118388433-B Production method of rubber vulcanizing agent 4,4' -dithiodimorpholine 山东昊宇新材料科技有限公司 2024-12-20 CN claimed
US-12152198-B2 Mesophase pitch for carbon fiber production using supercritical carbon dioxide TERRAPOWER, LLC (US) 2024-11-26 US claimed
CN-118955299-A Preparation method and application of diamine monomer containing trifluoromethyl and cyclohexyl 山东石油化工学院 2024-11-15 CN claimed
CN-118878488-A Synthesis method of chiral tetrahydrofuran-containing compound 北京化工大学 2024-11-01 CN claimed
CN-118834484-A Perfluoroether rubber composition, perfluoroether rubber, and preparation method and application thereof 中国石油化工股份有限公司 2024-10-25 CN claimed
CN-118831172-A Compound of intratumoral cell membrane receptor binding peptide coupled TLR7/8 agonist and application thereof 深圳威科森生物医药科技有限公司 2024-10-25 CN claimed
US-20240352012-A1 PAN-CASPASE INHIBITORS GEORGE MASON UNIVERSITY (US) 2024-10-24 US claimed
CN-118817943-A Method for detecting pyrophosphate content in sodium iron pyrophosphate 宁波容百新能源科技股份有限公司 2024-10-22 CN claimed
US-3940344-A Method of producing activated carbons from petroleum heavy materials in a reaction solvent with a sulfonating agent MARUZEN OIL CO., LTD. (JA) 1976-02-24 US claimed
US-3940390-A Process for the production of 2,3,4,5,6,7-hexahydrocyclopenta-(3)-1,3-oxazine-2,4-dione compounds BAYER AKTIENGESELLSCHAFT (DT) 1976-02-24 US claimed
US-3936308-A Photographic emulsions containing methine dyes having a 1H-imidazo[4,5-b]pyrazine nucleus EASTMAN KODAK COMPANY (US) 1976-02-03 US claimed
US-3936452-A Process of producing pyrimidyl thiocarbonates NITTO BOSEKI CO., LTD. (JA) 1976-02-03 US claimed
US-3935193-A ANTIBIOTICS TOYO JOZO KABUSHIKI KAISHA (JA) 1976-01-27 US claimed
US-3935294-A VAPOR PHASE CHROMATOGRAPHY TELLER ENVIRONMENTAL SYSTEMS, INC. (US) 1976-01-27 US claimed
US-3935196-A Useful pro-drug forms of theophylline INTERX RESEARCH CORPORATION (US) 1976-01-27 US claimed
US-3932375-A PROTECTING GROUPS NITTO BOSEKI CO. LTD. (JA) 1976-01-13 US claimed
US-3931270-A Process for producing 2-thia substituted 1,4 diones INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1976-01-06 US claimed
US-3931026-A ELECTRICALLY INSULATING ENCAPSULATING COMPOSITION FOR SEMICONDUCTOR DEVICES SEMIKRON GESELLSCHAFT FUR GLEICHRICHTERBAU UND ELEKTRONIK M.B.H. (DT) 1976-01-06 US claimed