SCHEMBL20845858

SCHEMBL20845858

NCCCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 8/20 0.58
▸ NPY1R P25929 3/20 0.54
▸ NPY2R P49146 3/20 0.54
▸ NPY4R P50391 3/20 0.54
▸ UTS2R Q9UKP6 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31105342 0.91 GHSR (0.52) GHSRNPY1RNPY2RNPY4R
SCHEMBL22546756 0.91 GHSR (0.58) GHSR
SCHEMBL29666286 0.90 GHSR (0.59) GHSR
SCHEMBL31105609 0.90 GHSR (0.53) GHSRNPY1RNPY2RNPY4RUTS2R
SCHEMBL30540726 0.89 GHSR (0.62) GHSR
SCHEMBL31202576 0.89 GHSR (0.66) GHSRNPY1RNPY2RNPY4RUTS2R
SCHEMBL31615095 0.88 GHSR (0.58) GHSR
SCHEMBL30751948 0.88 GHSR (0.56) GHSR
SCHEMBL31105637 0.88 GHSR (0.60) GHSR
SCHEMBL29666294 0.88 GHSR (0.56) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220016218-A1 LIPOPHILIC PEPTIDE PRODRUGS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2022-01-20 — — US disclosed
US-20200323962-A1 LIPOPHILIC PEPTIDE PRODRUGS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2020-10-15 — — US disclosed
WO-2019058367-A1 LIPOPHILIC PEPTIDE PRODRUGS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2019-03-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220016218-A1 LIPOPHILIC PEPTIDE PRODRUGS VIP, SI, TMPRSS15 GHSR 1990/4885NPY1R 1484/4885NPY2R 1637/4885
US-20200323962-A1 LIPOPHILIC PEPTIDE PRODRUGS VIP, SI, TMPRSS15 GHSR 1990/4885NPY1R 1484/4885NPY2R 1637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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