Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD44 | P16070 | 2/20 | 0.70 |
| ▸ | PNMT | P11086 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL16291557 | 0.86 | PNMT (0.86) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL9270264 | 0.86 | PNMT (0.66) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL19085 | 0.84 | PNMT (1.00) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28236302 | 0.84 | PNMT (1.00) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL29360217 | 0.84 | PNMT (1.00) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL1747872 | 0.84 | PNMT (0.68) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28083525 | 0.82 | PNMT (0.86) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL11213530 | 0.82 | PNMT (0.95) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL5411332 | 0.82 | PNMT (0.95) | CD44PNMTMAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL11457582 | 0.82 | PNMT (0.95) | CD44PNMTMAOBHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902218-B2 | Inhibit production of A beta -peptide; neurological disorders, Alzheimer's disease; (S)-2-((S)-3-Acetamido-3-((R)-sec-butyl)-2-oxopyrrolidin-1-yl)-N-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)propan-2-yl)-4-phenylbutanamide | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080153868-A1 | Substituted Tetrahydroisoquinolines as Beta-secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2008-06-26 | — | — | US | disclosed |
| US-7388007-B2 | Gamma-lactams as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-17 | — | — | US | disclosed |
| WO-2006026204-A2 | NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-03-09 | — | — | WO | disclosed |
| US-20060046984-A1 | Novel gamma-lactams as beta-secretase inhibitors | THOMPSON LORIN A III | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153868-A1 | Substituted Tetrahydroisoquinolines as Beta-secretase Inhibitors | BACE1, APP, BACE2 | CD44 4883/4885PNMT 1489/4885MAOB 1464/4885 |
| US-20060046984-A1 | Novel gamma-lactams as beta-secretase inhibitors | BACE1, BACE2, APP | CD44 4645/4885PNMT 3578/4885MAOB 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.