Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.66 |
| ▸ | CD44 | P16070 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL2084611 | 0.86 | CD44 (0.70) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL16291557 | 0.83 | PNMT (0.86) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28236302 | 0.81 | PNMT (1.00) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL19085 | 0.81 | PNMT (1.00) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL29360217 | 0.81 | PNMT (1.00) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28083525 | 0.79 | PNMT (0.86) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL11213530 | 0.79 | PNMT (0.95) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL4243903 | 0.79 | PNMT (0.95) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL11457582 | 0.79 | PNMT (0.95) | PNMTCD44MAOBHTR2C | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL20524019 | 0.79 | PNMT (0.95) | PNMTCD44MAOBHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674625-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013644-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |