Sugi Predict

Sugi Predict / Compounds / SCHEMBL2084824

SCHEMBL2084824

SCHEMBL2084824

CCOC(=O)c1c(NC(N)=O)nn2c(-c3ccc(C(F)(F)F)cc3)c(-c3ccccc3Cl)cnc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 7/20 0.42
▸ HPGD P15428 3/20 0.38
▸ GRM6 O15303 1/20 0.38
▸ MAPT P10636 3/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ NPSR1 Q6W5P4 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ FOS P01100 1/20 0.37
▸ JUN P05412 1/20 0.37
▸ NFKB1 P19838 1/20 0.37
▸ NFKB2 Q00653 1/20 0.37
▸ RELA Q04206 1/20 0.37
▸ DHODH Q02127 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ TSHR P16473 2/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2083585 0.88 GPR119 (0.45) GPR119HPGDGRM6MAPTALDH1A1
SCHEMBL4112426 0.88 GPR119 (0.41) GPR119HPGDMAPTALDH1A1NPSR1
SCHEMBL2087297 0.88 GPR119 (0.46) GPR119HPGDMAPTALDH1A1NPSR1
SCHEMBL2055587 0.87 NR3C1 (0.37) MAPTGAANR3C1
SCHEMBL2085513 0.85 GPR119 (0.46) GPR119HPGDMAPTALDH1A1NPSR1
SCHEMBL2085685 0.85 GPR119 (0.43) GPR119HPGDMAPTALDH1A1NPSR1
SCHEMBL2085486 0.85 GABRP (0.46) GPR119HPGDMAPTALDH1A1NPSR1
SCHEMBL2083460 0.84 GPR119 (0.43) GPR119HPGDMAPTALDH1A1NPSR1
SCHEMBL2084189 0.84 GPR119 (0.43) GPR119HPGDMAPTALDH1A1NPSR1
SCHEMBL2083400 0.83 GPR119 (0.42) GPR119HPGDMAPTALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8921380-B2 Pyrazolo[1,5-a] pyrimidine compounds as CB1 receptor antagonist MITSUBISHI TANABE PHARMA CORPORATION (JP) 2014-12-30 — — US disclosed
EP-2520577-B1 Pyrazolo[1,5-a]pyrimidine compounds as cb1 receptor antagonists MITSUBISHI TANABE PHARMA CORP (JP) 2013-12-11 — — EP disclosed
US-20120202992-A1 PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST TANIMOTO KOICHI (JP) 2012-08-09 — — US disclosed
US-8163759-B2 Pyrazolo[1,5-A] pyrimidine compounds as CB1 receptor antagonist MITSUBISHI TANABE PHARMA CORPORATION (JP) 2012-04-24 — — US disclosed
US-20090258867-A1 PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-10-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120202992-A1 PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST CNR1, CNR2, CCKAR GPR119 224/4885HPGD 3382/4885GRM6 425/4885
US-20090258867-A1 PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST CNR1, CNR2, CCKAR GPR119 190/4885HPGD 3367/4885GRM6 400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.