Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.56 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.56 |
| ▸ | PRKCI | P41743 | 8/20 | 0.54 |
| ▸ | IKBKB | O14920 | 4/20 | 0.54 |
| ▸ | CHUK | O15111 | 4/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | GRK5 | P34947 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856991 | 0.82 | PRKCI (0.57) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL2239087 | 0.78 | IKBKB (0.61) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL4792517 | 0.77 | IKBKB (0.70) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL1718599 | 0.75 | NUDT1 (0.69) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL31420118 | 0.74 | CCNK (0.58) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL14020099 | 0.74 | CCNK (0.58) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL1718138 | 0.74 | NUDT1 (0.67) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL1717710 | 0.74 | PRKCI (0.61) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL2240671 | 0.73 | AURKB (0.71) | CCNKCDK12PRKCIIKBKBCHUK | |
| SCHEMBL1838406 | 0.72 | NUDT1 (0.67) | CCNKCDK12PRKCIIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684776-B1 | HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE | UNIV NOTTINGHAM (GB) | 2023-11-01 | — | — | EP | disclosed |
| WO-2019058132-A1 | HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE | THE UNIVERSITY OF NOTTINGHAM (GB) | 2019-03-28 | — | — | WO | disclosed |