Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | JUN | P05412 | 4/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.39 |
| ▸ | RELA | Q04206 | 4/20 | 0.39 |
| ▸ | FOS | P01100 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15635108 | 0.89 | KDM4E (0.46) | SYKKDM4EALDH1A1JUNNFKB1 | |
| SCHEMBL15636201 | 0.86 | SYK (0.45) | SYKKDM4EALDH1A1JUNNFKB1 | |
| SCHEMBL2087996 | 0.85 | ALDH1A1 (0.46) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15635500 | 0.82 | SYK (0.42) | SYKKDM4EALDH1A1JUNNFKB1 | |
| SCHEMBL2086011 | 0.80 | NPSR1 (0.44) | KDM4EALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL15636051 | 0.79 | SYK (0.43) | SYKKDM4EALDH1A1JUNNFKB1 | |
| SCHEMBL1373222 | 0.79 | SYK (0.43) | SYKKDM4EALDH1A1JUNNFKB1 | |
| SCHEMBL6217104 | 0.78 | HPGD (0.46) | SYKKDM4EALDH1A1JUNNFKB1 | |
| SCHEMBL13063042 | 0.78 | TUBB4A (0.46) | KDM4EALDH1A1MAPTCYP3A4HPGD | |
| SCHEMBL3204442 | 0.77 | GAA (0.45) | SYKKDM4EALDH1A1JUNNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897612-B2 | Substituted 1,8-naphthyridinecarboxamides for use as prolyl hydroxylase inhibitors | GlaxoSmithKline, LLC (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090082357-A1 | Prolyl Hydroxylase Inhibitors | GLAXOSMITHKLINE LLC | 2009-03-26 | — | — | US | disclosed |
| EP-1991227-A2 | PROLYL HYDROXYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007103905-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| US-20070213335-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082357-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | SYK 4534/4885KDM4E 566/4885ALDH1A1 319/4885 |
| US-20070213335-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | SYK 4534/4885KDM4E 566/4885ALDH1A1 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.