Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FGB | P02675 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239249 | 0.84 | RAPGEF4 (0.44) | RAPGEF4NR3C1PGRNR3C2MEN1 | |
| SCHEMBL30697862 | 0.84 | RAPGEF4 (0.44) | RAPGEF4NR3C1PGRNR3C2MEN1 | |
| SCHEMBL1823536 | 0.82 | RAPGEF4 (0.49) | RAPGEF4TDP1NPSR1KMT2APOLB | |
| SCHEMBL5236778 | 0.81 | LMNA (0.43) | RAPGEF4MAPTTDP1NPSR1HTT | |
| SCHEMBL5384451 | 0.81 | RAPGEF4 (0.41) | RAPGEF4MAPTTDP1NPSR1HTT | |
| SCHEMBL5234362 | 0.79 | LMNA (0.41) | RAPGEF4MAPTTDP1NPSR1HTT | |
| SCHEMBL1694111 | 0.79 | RAPGEF4 (0.41) | RAPGEF4MAPTTDP1NPSR1HTT | |
| SCHEMBL3461956 | 0.78 | RAPGEF4 (0.39) | RAPGEF4MAPTTDP1NPSR1HTT | |
| SCHEMBL2968699 | 0.77 | RAPGEF4 (0.38) | RAPGEF4MAPTTDP1NPSR1HTT | |
| SCHEMBL5230082 | 0.77 | RAPGEF4 (0.45) | RAPGEF4MAPTTDP1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730840-B2 | Substituted tetrahydroisoquinoline ethylbenzamide anti-cancer agents | FLORIDA A&M UNIVERSITY (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190100495-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE ETHYLBENZAMIDE ANTI-CANCER AGENTS | FLORIDA A&M UNIVERSITY | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100495-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE ETHYLBENZAMIDE ANTI-CANCER AGENTS | BRDT, ESR2, TEAD4 | RAPGEF4 1292/4885MAPT 4725/4885TDP1 1255/4885 |
| US-10730840-B2 | Substituted tetrahydroisoquinoline ethylbenzamide anti-cancer agents | BRDT, ESR2, TEAD4 | RAPGEF4 1292/4885MAPT 4725/4885TDP1 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.