Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234362 | 0.89 | LMNA (0.41) | LMNASMN1; SMN2MCOLN3L3MBTL1ALDH1A1 | |
| SCHEMBL1694111 | 0.86 | RAPGEF4 (0.41) | LMNASMN1; SMN2MCOLN3L3MBTL1ALDH1A1 | |
| SCHEMBL1823536 | 0.86 | RAPGEF4 (0.49) | LMNARAPGEF4CA1CA2CA9 | |
| SCHEMBL5236783 | 0.85 | LMNA (0.43) | LMNASMN1; SMN2MCOLN3L3MBTL1ALDH1A1 | |
| SCHEMBL20854534 | 0.81 | RAPGEF4 (0.40) | LMNASMN1; SMN2MCOLN3L3MBTL1ALDH1A1 | |
| SCHEMBL21835146 | 0.79 | RAPGEF4 (0.55) | LMNASMN1; SMN2L3MBTL1ALDH1A1RAPGEF4 | |
| SCHEMBL1048207 | 0.79 | CA12 (0.46) | SMN1; SMN2L3MBTL1CA1CA2CA9 | |
| SCHEMBL5384451 | 0.79 | RAPGEF4 (0.41) | LMNASMN1; SMN2MCOLN3L3MBTL1ALDH1A1 | |
| SCHEMBL22228647 | 0.78 | RAPGEF4 (0.39) | LMNASMN1; SMN2L3MBTL1ALDH1A1RAPGEF4 | |
| SCHEMBL1810783 | 0.78 | RAPGEF4 (0.38) | ALDH1A1RAPGEF4CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |